Harmonizome 3.0

FGR proto-oncogene, Src family tyrosine kinase

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fgr in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase FGR from the curated KEA Substrates of Kinases dataset.

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for FGR from the MSigDB Cancer Gene Co-expression Modules dataset.

From NURSA Protein-Protein Interactions

interacting proteins for FGR from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for FGR from the Pathway Commons Protein-Protein Interactions dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase FGR from the curated PhosphoSitePlus Substrates of Kinases dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the FGR gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From Kinase Library Tyrosine Kinome Atlas

substrates of the kinase FGR from the Kinase Library Tyrosine Kinome Atlas dataset.

From CORUM Protein Complexes

proteins in the Fgr-Pyk2-p190RhoGap complex protein complex from the CORUM Protein Complexes dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase Fgr protein domain from the InterPro Predicted Protein Domain Annotations dataset.