Harmonizome 3.0

interleukin-1 receptor-associated kinase 3

This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term irak3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase IRAK3 from the curated KEA Substrates of Kinases dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for IRAK3 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the IRAK3 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CORUM Protein Complexes

proteins in the IRAK1-IRAK3 complex protein complex from the CORUM Protein Complexes dataset.

From DGIdb Drug Targets 2026

interacting proteins for the IRAK3 PROTAC 23 drug from theDGIdb Drug Targets 2026 dataset.