Harmonizome 3.0

MDS1 and EVI1 complex locus

The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the MECOM-23826213-KASUMI-MOUSE transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Targets 2022

target genes of the MECOM-23826213-KASUMI-MOUSE transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets

target genes of the MECOM transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

From JASPAR Predicted Transcription Factor Targets

target genes of the MECOM transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for MECOM from the Pathway Commons Protein-Protein Interactions dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the MECOM-associated syndrome phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From JASPAR Predicted Mouse Transcription Factor Targets 2025

target genes of the Mecom transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2925 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11437185-41467_2024_50986_MOESM4_ESM.xlsx-MECOM-IP-MS-Gene_names_MECOM transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the MECOM gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.