OGDH

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Results for "OGDH": 1 gene, 5 gene sets

Name
OGDH Gene oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
OGDH Gene Set From NURSA Protein-Protein Interactions interacting proteins for OGDH from the NURSA Protein-Protein Interactions dataset.
OGDH Gene Set From Pathway Commons Protein-Protein Interactions interacting proteins for OGDH from the Pathway Commons Protein-Protein Interactions dataset.
OGDH Gene Set From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the OGDH gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
OGDH Gene Set From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the OGDH gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.
OGDH complex synthesizes succinyl-CoA from 2-OG Gene Set From Reactome Pathways 2024 proteins participating in the OGDH complex synthesizes succinyl-CoA from 2-OG pathway from the Reactome Pathways 2024 dataset.