Harmonizome 3.0

platelet factor 4

This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pf4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for PF4 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the PF4 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the PF4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CellMarker Gene-Cell Type Associations

genes associated with the Pf4+ M2 macrophage_Blood vessel_Mouse cell type from the CellMarker Gene-Cell Type Associations dataset.