Harmonizome 3.0

progastricsin (pepsinogen C)

This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pgc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for PGC from the Pathway Commons Protein-Protein Interactions dataset.

From Biocarta Pathways

proteins participating in the regulation of pgc-1a pathway from the Biocarta Pathways dataset.

From CORUM Protein Complexes

proteins in the SIRT1-HNF4-alpha-PGC-1-alpha complex, in response to fasting protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the PGC-1-SRp40-SRp55-SRp75 complex protein complex from the CORUM Protein Complexes dataset.

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the PGC-1alpha_Deficiency_GDS4904_311_mouse_Aged gastrocnemius muscle - 24 months gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the PGC-1alpha_Deficiency_GDS4904_310_mouse_Aged gastrocnemius muscle - 10 weeks gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From Reactome Pathways 2014

proteins participating in the Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway from the Reactome Pathways dataset.

From CellMarker Gene-Cell Type Associations

genes associated with the Primordial germ cell (PGC)_Testis_Human cell type from the CellMarker Gene-Cell Type Associations dataset.

From CellMarker Gene-Cell Type Associations

genes associated with the Primordial germ cell (PGC)_Sperm_Human cell type from the CellMarker Gene-Cell Type Associations dataset.

From Reactome Pathways 2024

proteins participating in the Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway from the Reactome Pathways 2024 dataset.