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PRKCZ Geneprotein kinase C, zeta Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
PRKCZ-AS1 GenePRKCZ antisense RNA 1 |
prkcz Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term prkcz in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
PRKCZ Gene SetFrom Hub Proteins Protein-Protein Interactions interacting proteins for hub protein PRKCZ from the curated Hub Proteins Protein-Protein Interactions dataset. |
PRKCZ Gene SetFrom KEA Substrates of Kinases substrates of the kinase PRKCZ from the curated KEA Substrates of Kinases dataset. |
PRKCZ Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for PRKCZ from the Pathway Commons Protein-Protein Interactions dataset. |
PRKCZ Gene SetFrom PhosphoSitePlus Substrates of Kinases substrates of the kinase PRKCZ from the curated PhosphoSitePlus Substrates of Kinases dataset. |
PRKCZ Gene SetFrom LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the PRKCZ gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. |
Limd1-p62-Traf6-Prkcz complex Gene Setproteins in the Limd1-p62-Traf6-Prkcz complex protein complex from the CORUM Protein Complexes dataset. |
Estrogen-stimulated signaling through PRKCZ Gene Setproteins participating in the Estrogen-stimulated signaling through PRKCZ pathway from the Reactome Pathways 2024 dataset. |