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PTK6 Geneprotein tyrosine kinase 6 The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] |
ptk6 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term ptk6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
PTK6 Gene SetFrom KEA Substrates of Kinases substrates of the kinase PTK6 from the curated KEA Substrates of Kinases dataset. |
PTK6 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for PTK6 from the Pathway Commons Protein-Protein Interactions dataset. |
PTK6 Gene SetFrom PhosphoSitePlus Substrates of Kinases substrates of the kinase PTK6 from the curated PhosphoSitePlus Substrates of Kinases dataset. |
PTK6 Gene SetFrom LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the PTK6 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. |
ERBB2 Activates PTK6 Signaling Gene Setproteins participating in the ERBB2 Activates PTK6 Signaling pathway from the Reactome Pathways 2024 dataset. |
PTK6 Activates STAT3 Gene Setproteins participating in the PTK6 Activates STAT3 pathway from the Reactome Pathways 2024 dataset. |
PTK6 Down-Regulation Gene Setproteins participating in the PTK6 Down-Regulation pathway from the Reactome Pathways 2024 dataset. |
PTK6 Expression Gene Setproteins participating in the PTK6 Expression pathway from the Reactome Pathways 2024 dataset. |
PTK6 Regulates Cell Cycle Gene Setproteins participating in the PTK6 Regulates Cell Cycle pathway from the Reactome Pathways 2024 dataset. |
PTK6 Regulates Proteins Involved in RNA Processing Gene Setproteins participating in the PTK6 Regulates Proteins Involved in RNA Processing pathway from the Reactome Pathways 2024 dataset. |
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases Gene Setproteins participating in the PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases pathway from the Reactome Pathways 2024 dataset. |
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 Gene Setproteins participating in the PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 pathway from the Reactome Pathways 2024 dataset. |
PTK6 promotes HIF1A stabilization Gene Setproteins participating in the PTK6 promotes HIF1A stabilization pathway from the Reactome Pathways 2024 dataset. |
Signaling by PTK6 Gene Setproteins participating in the Signaling by PTK6 pathway from the Reactome Pathways 2024 dataset. |