Harmonizome 3.0

RAD50 homolog (S. cerevisiae)

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term rad50 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From NURSA Protein-Protein Interactions

interacting proteins for RAD50 from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for RAD50 from the Pathway Commons Protein-Protein Interactions dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the RAD50 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the MRN complex (MRE11-RAD50-NBS1 complex) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the MDC1-MRE11-RAD50-NBS1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BRCA1-RAD50-MRE11-NBS1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the RAD50-BRCA1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the R/M complex (RAD50-MRE11 complex) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the MRN complex (MRE11-RAD50-NBN complex) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the MRE11A-RAD50-NBN-TRF2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP complex) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the RAD50-MRE11-NBN-p200-p350 complex protein complex from the CORUM Protein Complexes dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the DNA repair protein Rad50, eukaryotes protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the RAD50, zinc hook protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From Reactome Pathways 2014

proteins participating in the Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks pathway from the Reactome Pathways dataset.