Harmonizome 3.0

recombination signal binding protein for immunoglobulin kappa J region

The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]

RBPJ pseudogene 1

RBPJ pseudogene 2

RBPJ pseudogene 4

RBPJ pseudogene 5

RBPJ pseudogene 6

RBPJ pseudogene 7

corepressor interacting with RBPJ, 1 pseudogene 1

corepressor interacting with RBPJ, 1 pseudogene 2

RBPJ pseudogene 3

corepressor interacting with RBPJ, 1

Enables histone deacetylase binding activity; protein kinase binding activity; and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in centrosome and nuclear speck. Part of protein-containing complex. [provided by Alliance of Genome Resources, Mar 2025]

RBPJ interacting and tubulin associated 1

Enables tubulin binding activity. Involved in negative regulation of Notch signaling pathway and nuclear export. Located in centrosome; cytoplasm; and nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]

corepressor of RBPJ and splicing regulator

Enables histone deacetylase binding activity; protein kinase binding activity; and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in centrosome and nuclear speck. Part of protein-containing complex. [provided by Alliance of Genome Resources, Mar 2025]

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the RBPJ-21746931-IB4-LCL-HUMAN transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Targets 2022

target genes of the RBPJ-21746931-IB4-LCL-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the RBPJ-22232070-NCS-MOUSE transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Targets

target genes of the RBPJ transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

From CORUM Protein Complexes

proteins in the RBPJ-NotchIC-Mastermind complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the PTF1 complex (Ptf1a, Tcf12, Rbpj) protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term rbpj in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for RBPJ from the Pathway Commons Protein-Protein Interactions dataset.

From ChEA Transcription Factor Targets 2022

target genes of the RBPJ-22232070-NCS-MOUSE transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the RBPJ transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the RBPJ gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.