Harmonizome 3.0

SET domain, bifurcated 1

This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011]

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the SETDB1-19884255-MESC-mouse transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Targets

target genes of the SETDB1 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

From CORUM Protein Complexes

proteins in the SETDB1-containing HMTase complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the MBD1-MCAF1-SETDB1 complex protein complex from the CORUM Protein Complexes dataset.

From ENCODE Transcription Factor Targets

target genes of the SETDB1 transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term setdb1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein SETDB1 from the curated Hub Proteins Protein-Protein Interactions dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Histone-lysine N-methyltransferase SETDB1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From NURSA Protein Complexes

proteins in the BL540 (SETDB1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein-Protein Interactions

interacting proteins for SETDB1 from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for SETDB1 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the SETDB1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the SETDB1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.