Harmonizome 3.0

SIN3 transcription regulator family member A

The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]

Sin3A-associated protein, 30kDa

Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008]

Sin3A-associated protein, 130kDa

SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]

Sin3A-associated protein, 25kDa

Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Mar 2025]

Sin3A-associated protein, 18kDa

Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008]

Sin3A-associated protein, 30kDa pseudogene

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the SIN3A-21632747-MESC-MOUSE transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Targets

target genes of the SIN3A transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

From CORUM Protein Complexes

proteins in the SKI-NCOR1-SIN3A-HDAC1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SMAD3-cSKI-SIN3A-HDAC1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the PU.1-Sin3A-Hdac-MeCP2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the MeCP2-SIN3A-HDAC complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Smrt-Sin3A-Hdac7 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Hdac1-Mecp2-Rcor1-Sin3a complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BRM-SIN3A complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the NK-3-Groucho-HIPK2-SIN3A-RbpA48-HDAC1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BRG1-SIN3A-HDAC containing SWI/SNF remodeling complex I protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BRM-SIN3A-HDAC complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the PU.1-SIN3A-HDAC complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BRG1-SIN3A complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the HERP1/HEY2-NCOR-SIN3A complex protein complex from the CORUM Protein Complexes dataset.

From ENCODE Transcription Factor Targets

target genes of the SIN3A transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sin3a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein SIN3A from the curated Hub Proteins Protein-Protein Interactions dataset.

From NURSA Protein Complexes

proteins in the BL2730 (SIN3A) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL2728 (SIN3A) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL2729 (SIN3A) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the SC-5299 (SIN3A) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL2731 (SIN3A) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein-Protein Interactions

interacting proteins for SIN3A from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for SIN3A from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the SIN3A gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the SIN3A-related intellectual disability syndrome due to a point mutation phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the SIN3A-related intellectual disability syndrome phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the SIN3A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.