Harmonizome 3.0

spermidine synthase

The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq, Jul 2008]

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical SRM 1597 from the curated CTD Gene-Chemical Interactions dataset.

From CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the enoxacin-1597 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

From NURSA Protein Complexes

proteins in the EPI-1597-1 (BLNK) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term srm in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for SRM from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the SRM gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the SRM gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.