Harmonizome 3.0

signal transducer and activator of transcription 2, 113kDa

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. The protein mediates innate antiviral activity. Mutations in this gene result in Immunodeficiency 44. [provided by RefSeq, Aug 2020]

From ENCODE Transcription Factor Targets

target genes of the STAT2 transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for STAT2 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the STAT2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From JASPAR Predicted Mouse Transcription Factor Targets 2025

target genes of the Stat2 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2925 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the STAT2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From GO Biological Process Annotations 2015

genes participating in the tyrosine phosphorylation of stat2 protein biological process from the curated GO Biological Process Annotations 2015 dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the STAT1::STAT2 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC7902901-Table_12.xlsx-STAT2-Unnamed_7_STAT2 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC6137307-mmc2.xlsx-STAT2-IFNa-Table_S1_STAT2-IFNa_Related_to_Figures_1_4_STAT2 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.