Harmonizome 3.0

poliovirus receptor-related 1 (herpesvirus entry mediator C)

This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]

poliovirus receptor-related 2 (herpesvirus entry mediator B)

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Human herpesvirus 8, susceptibility to

long intergenic non-protein coding RNA 488

RNA, 5S ribosomal pseudogene 488

microRNA 488

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

zinc finger protein 488

Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in oligodendrocyte development and regulation of DNA-templated transcription. Predicted to act upstream of or within negative regulation of DNA-templated transcription and positive regulation of oligodendrocyte differentiation. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Mar 2025]

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Saimiriine herpesvirus 2 (strain 488) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Saimiriine herpesvirus 2 (strain 11) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Human herpesvirus 1 (strain Patton) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Human herpesvirus 1 (strain 17) from the Virus MINT Protein-Virus Interactions dataset.

From CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the iloprost-488 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

From MiRTarBase microRNA Targets

target genes of the hsa-miR-488-5p microRNA in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.

From MiRTarBase microRNA Targets

target genes of the hsa-miR-488-3p microRNA in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.

From TargetScan Predicted Conserved microRNA Targets

target genes of the hsa-miR-488 microRNA predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.

From TargetScan Predicted Nonconserved microRNA Targets

target genes of the hsa-miR-488 microRNA predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.

From DGIdb Drug Targets 2026

interacting proteins for the ALEXA-488-TELENZEPINE drug from theDGIdb Drug Targets 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-488-NFKB1_NFKB1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-488-GMEB1_GMEB1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC10265161-ACEL-22-e13841-s002.pdf-488-TP53_TP53 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC12486367-Supplementary_Data2.pdf-488-ZNF445_ZNF445 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term herpesvirus in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From HPO Gene-Disease Associations

genes associated with the susceptibility to herpesvirus phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

From OMIM Gene-Disease Associations

genes associated with the {human herpesvirus 8, susceptibility to} phenotype from the curated OMIM Gene-Disease Associations dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Human herpesvirus 1 from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Human herpesvirus 6 from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Human herpesvirus 8 from the Virus MINT Protein-Virus Interactions dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Infection By Human Herpesvirus in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Human Herpesvirus 8 Infection in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From KEGG Pathways 2026

proteins participating in the Virion - Herpesvirus pathway from the KEGG Pathways 2026 dataset.

From KEGG Pathways 2026

proteins participating in the Kaposi sarcoma-associated herpesvirus infection pathway from the KEGG Pathways 2026 dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term strain in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Sendai virus (strain Fushimi) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Fowl adenovirus 1 (strain CELO / Phelps) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Cottontail rabbit papillomavirus (strain Kansas) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Epstein-Barr virus (strain GD1) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Epstein-Barr virus (strain B95-8) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Murine polyomavirus (strain 3) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Rous sarcoma virus (strain Schmidt-Ruppin A) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Influenza A virus (strain A/Puerto Rico/8/34 H1N1) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Poliovirus type 1 (strain Sabin) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Influenza A virus (strain A/Aichi/2/1968 H3N2) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Hepatitis E virus (strain Burma) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Hepatitis E virus (strain Mexico) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Vaccinia virus (strain Copenhagen) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Avian sarcoma virus (strain PR2257) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Vaccinia virus (strain Western Reserve / WR) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Vaccinia virus (strain L-IVP) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Simian virus 5 (strain W3) from the Virus MINT Protein-Virus Interactions dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Left ventricular global radial strain phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Left ventricular global circumferential strain (MTAG) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Left ventricular global radial strain (MTAG) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Left ventricular global longitudinal strain (MTAG) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Left ventricular global circumferential strain phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Left ventricular global longitudinal strain phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the COMMENSAL BACTERIAL STRAIN FORMULATION VE800 drug from theDGIdb Drug Targets 2026 dataset.