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TICAM1 Genetoll-like receptor adaptor molecule 1 This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. Mutations in this gene are associated with encephalopathy, acute, infection-induced. [provided by RefSeq, Jul 2020] |
ticam1 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term ticam1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
TICAM1 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for TICAM1 from the Pathway Commons Protein-Protein Interactions dataset. |
TICAM1 Gene SetFrom LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the TICAM1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. |
TICAM1-TICAM2-TLR4 complex Gene Setproteins in the TICAM1-TICAM2-TLR4 complex protein complex from the CORUM Protein Complexes dataset. |
TICAM1 deficiency - HSE Gene Setproteins participating in the TICAM1 deficiency - HSE pathway from the Reactome Pathways 2024 dataset. |
TICAM1, RIP1-mediated IKK complex recruitment Gene Setproteins participating in the TICAM1, RIP1-mediated IKK complex recruitment pathway from the Reactome Pathways 2024 dataset. |
TICAM1,TRAF6-dependent induction of TAK1 complex Gene Setproteins participating in the TICAM1,TRAF6-dependent induction of TAK1 complex pathway from the Reactome Pathways 2024 dataset. |
TICAM1-dependent activation of IRF3/IRF7 Gene Setproteins participating in the TICAM1-dependent activation of IRF3/IRF7 pathway from the Reactome Pathways 2024 dataset. |
TLR3-mediated TICAM1-dependent programmed cell death Gene Setproteins participating in the TLR3-mediated TICAM1-dependent programmed cell death pathway from the Reactome Pathways 2024 dataset. |
TRIF (TICAM1)-mediated TLR4 signaling Gene Setproteins participating in the TRIF (TICAM1)-mediated TLR4 signaling pathway from the Reactome Pathways 2024 dataset. |