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TLR9 Genetoll-like receptor 9 The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Aug 2017] |
tlr9 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term tlr9 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
TLR9 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for TLR9 from the Pathway Commons Protein-Protein Interactions dataset. |
TLR9 Gene SetFrom LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the TLR9 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. |
Toll Like Receptor 9 (TLR9) Cascade Gene Setproteins participating in the Toll Like Receptor 9 (TLR9) Cascade pathway from the Reactome Pathways dataset. |
Toll Like Receptor 9 (TLR9) Cascade Gene Setproteins participating in the Toll Like Receptor 9 (TLR9) Cascade pathway from the Reactome Pathways 2024 dataset. |
CPG OLIGODEOXYNUCLEOTIDE TLR9 AGONIST DV281 Gene Setinteracting proteins for the CPG OLIGODEOXYNUCLEOTIDE TLR9 AGONIST DV281 drug from theDGIdb Drug Targets 2026 dataset. |