Harmonizome 3.0

vacuolar protein sorting 35 homolog (S. cerevisiae)

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vps35 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for VPS35 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the VPS35 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the VPS35 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the Vps29-Vps35-Vps26a complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26B) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the VPS35-VPS29-VPS26A complex protein complex from the CORUM Protein Complexes dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Vacuolar protein sorting-associated protein 35, Vps35 protein domain from the InterPro Predicted Protein Domain Annotations dataset.