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YWHAE Genetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008] |
ywhae Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term ywhae in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
YWHAE Gene SetFrom Hub Proteins Protein-Protein Interactions interacting proteins for hub protein YWHAE from the curated Hub Proteins Protein-Protein Interactions dataset. |
YWHAE Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for YWHAE from the Pathway Commons Protein-Protein Interactions dataset. |
YWHAE Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the YWHAE gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |
HSF1-YWHAE complex Gene Setproteins in the HSF1-YWHAE complex protein complex from the CORUM Protein Complexes dataset. |
RAF1-MAP2K1-YWHAE complex Gene Setproteins in the RAF1-MAP2K1-YWHAE complex protein complex from the CORUM Protein Complexes dataset. |
BRAF-MAP2K1-MAP2K2-YWHAE complex Gene Setproteins in the BRAF-MAP2K1-MAP2K2-YWHAE complex protein complex from the CORUM Protein Complexes dataset. |
MAP2K1-BRAF-RAF1-YWHAE-KSR1 complex Gene Setproteins in the MAP2K1-BRAF-RAF1-YWHAE-KSR1 complex protein complex from the CORUM Protein Complexes dataset. |
17p13 3 YWHAE copy number variation Gene SetFrom WikiPathways Pathways 2024 proteins participating in the 17p13 3 YWHAE copy number variation pathway from the WikiPathways Pathways 2024 dataset. |