Harmonizome 3.0

autoimmune regulator

This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term aire in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for AIRE from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the AIRE gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the AIRE gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the AIRE homodimer complex protein complex from the CORUM Protein Complexes dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Autoimmune regulator, AIRE protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From CellMarker Gene-Cell Type Associations

genes associated with the AIRE-enriched cell_Tonsil_Human cell type from the CellMarker Gene-Cell Type Associations dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC8582123-13073_2021_996_MOESM3_ESM.xlsx-AIRE-HIT_AIRE transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.