Harmonizome 3.0

death-domain associated protein

This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

From NURSA Protein Complexes

proteins in the BL5619 (DAXX) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the ATRX-DAXX complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the DAXX-AXIN complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the DAXX-DNMT1-DMAP1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Daxx-Axin-p53 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the DAXX-Axin-p53-HIPK2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (SPOP, DAXX, CUL3) protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term daxx in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Daxx protein protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From NURSA Protein Complexes

proteins in the BL5618 (DAXX) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for DAXX from the Pathway Commons Protein-Protein Interactions dataset.

From Reactome Pathways 2024

proteins participating in the Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations pathway from the Reactome Pathways 2024 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the DAXX gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.