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SHC1 GeneSHC (Src homology 2 domain containing) transforming protein 1 This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] |
BL8103 (SHC1) Gene Setproteins in the BL8103 (SHC1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset. |
ITGA6-ITGB4-SHC1-GRB2 complex Gene Setproteins in the ITGA6-ITGB4-SHC1-GRB2 complex protein complex from the CORUM Protein Complexes dataset. |
shc1 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term shc1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
SHC1 Gene SetFrom Hub Proteins Protein-Protein Interactions interacting proteins for hub protein SHC1 from the curated Hub Proteins Protein-Protein Interactions dataset. |
EPI-1629-1 (SHC1) Gene Setproteins in the EPI-1629-1 (SHC1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset. |
SHC1 Gene SetFrom NURSA Protein-Protein Interactions interacting proteins for SHC1 from the NURSA Protein-Protein Interactions dataset. |
SHC1 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for SHC1 from the Pathway Commons Protein-Protein Interactions dataset. |
SHC1 events in EGFR signaling Gene Setproteins participating in the SHC1 events in EGFR signaling pathway from the Reactome Pathways dataset. |
SHC1 events in ERBB4 signaling Gene Setproteins participating in the SHC1 events in ERBB4 signaling pathway from the Reactome Pathways dataset. |
SHC1 events in ERBB2 signaling Gene Setproteins participating in the SHC1 events in ERBB2 signaling pathway from the Reactome Pathways dataset. |
SHC1 Gene SetFrom LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the SHC1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. |
SHC1 events in EGFR signaling Gene Setproteins participating in the SHC1 events in EGFR signaling pathway from the Reactome Pathways 2024 dataset. |
SHC1 events in ERBB2 signaling Gene Setproteins participating in the SHC1 events in ERBB2 signaling pathway from the Reactome Pathways 2024 dataset. |
SHC1 events in ERBB4 signaling Gene Setproteins participating in the SHC1 events in ERBB4 signaling pathway from the Reactome Pathways 2024 dataset. |
SHC1 Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the SHC1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |