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BMF GeneBcl2 modifying factor The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
bmf Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term bmf in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
BMF Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for BMF from the Pathway Commons Protein-Protein Interactions dataset. |
BMF Gene SetFrom LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the BMF gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. |
BMF Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the BMF gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |
Activation of BMF and translocation to mitochondria Gene Setproteins participating in the Activation of BMF and translocation to mitochondria pathway from the Reactome Pathways dataset. |
Activation of BMF and translocation to mitochondria Gene Setproteins participating in the Activation of BMF and translocation to mitochondria pathway from the Reactome Pathways 2024 dataset. |
FLT3 INHIBITOR BMF-500 Gene Setinteracting proteins for the FLT3 INHIBITOR BMF-500 drug from theDGIdb Drug Targets 2026 dataset. |