COMT

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Results for "COMT": 1 gene, 7 gene sets

Name
COMT Gene catechol-O-methyltransferase Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
comt Gene Set From GeneRIF Biological Term Annotations genes co-occuring with the biological term comt in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
COMT Gene Set From Pathway Commons Protein-Protein Interactions interacting proteins for COMT from the Pathway Commons Protein-Protein Interactions dataset.
COMT Gene Set From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the COMT gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
COMT Gene Set From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the COMT gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.
O-methyltransferase COMT-type Gene Set From InterPro Predicted Protein Domain Annotations proteins predicted to have the O-methyltransferase COMT-type protein domain from the InterPro Predicted Protein Domain Annotations dataset.
Enzymatic degradation of dopamine by COMT Gene Set From Reactome Pathways 2014 proteins participating in the Enzymatic degradation of dopamine by COMT pathway from the Reactome Pathways dataset.
Enzymatic degradation of dopamine by COMT Gene Set From Reactome Pathways 2024 proteins participating in the Enzymatic degradation of dopamine by COMT pathway from the Reactome Pathways 2024 dataset.