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CXCR1 Genechemokine (C-X-C motif) receptor 1 The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008] |
cxcr1 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term cxcr1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
CXCR1 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for CXCR1 from the Pathway Commons Protein-Protein Interactions dataset. |
CXCR1 Gene SetFrom LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the CXCR1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. |
IL8- and CXCR1-mediated signaling events Gene SetFrom PID Pathways proteins participating in the IL8- and CXCR1-mediated signaling events pathway from the PID Pathways dataset. |
CXCR1 chemokine receptor binding Gene SetFrom GO Molecular Function Annotations 2023 genes performing the CXCR1 chemokine receptor binding molecular function from the curated GO Molecular Function Annotations 2023 dataset. |
CXCR1 chemokine receptor binding Gene SetFrom GO Molecular Function Annotations 2025 genes performing the CXCR1 chemokine receptor binding molecular function from the curated GO Molecular Function Annotations 2025 dataset. |