Harmonizome 3.0

hepatocyte nuclear factor 4, alpha

The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]

HNF4A antisense RNA 1

From ChEA Transcription Factor Targets

target genes of the HNF4A transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

From ENCODE Transcription Factor Targets

target genes of the HNF4A transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term hnf4a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From JASPAR Predicted Transcription Factor Targets

target genes of the HNF4A transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for HNF4A from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the HNF4A gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the HNF4A transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the HNF4A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the HNF4A-19822575-HepG2-human transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the HNF4A-19761587-HUMAN INTESTINAL CELL LINE CACO-2-human transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From CORUM Protein Complexes

proteins in the HNF4A-SUB1 complex protein complex from the CORUM Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the SC-8987 (HNF4A) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From ChEA Transcription Factor Targets 2022

target genes of the HNF4A-19761587-CACO-2-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the Hyperinsulinism due to HNF4A deficiency phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC10197896-ijbsv19p2613s1.pdf-3-HNF4A-AS1_HNF4A transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC6292939-41598_2018_36168_MOESM8_ESM.xlsx-HNF4A-Non-metastasis_HNF4A transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC6292939-41598_2018_36168_MOESM8_ESM.xlsx-HNF4A-Unnamed_1_HNF4A transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11558691-tables5_bbae592.xlsx-HNF4A-Genes_HNF4A transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.