IFIH1

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Results for "IFIH1": 1 gene, 8 gene sets

Name
IFIH1 Gene interferon induced with helicase C domain 1 IFIH1 encodes MDA5 which is an intracellular sensor of viral RNA that triggers the innate immune response. Sensing RNA length and secondary structure, MDA5 binds dsRNA oligonucleotides with a modified DExD/H-box helicase core and a C-terminal domain, thus leading to a proinflammatory response that includes interferons. It has been shown that Coronaviruses (CoVs) as well as various other virus families, are capable of evading the MDA5-dependent interferon response, thus impeding the activation of the innate immune response to infection. MDA5 has also been shown to play an important role in enhancing natural killer cell function in malaria infection. In addition to its protective role in antiviral responses, MDA5 has been implicated in autoimmune and autoinflammatory diseases such as type 1 diabetes, systemic lupus erythematosus, and Aicardi-Goutieres syndrome[provided by RefSeq, Jul 2020]
ifih1 Gene Set From GeneRIF Biological Term Annotations genes co-occuring with the biological term ifih1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
IFIH1 Gene Set From Pathway Commons Protein-Protein Interactions interacting proteins for IFIH1 from the Pathway Commons Protein-Protein Interactions dataset.
IFIH1 Gene Set From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the IFIH1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
IFIH1 Gene Set From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the IFIH1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.
DDX58/IFIH1-mediated induction of interferon-alpha/beta Gene Set From Reactome Pathways 2024 proteins participating in the DDX58/IFIH1-mediated induction of interferon-alpha/beta pathway from the Reactome Pathways 2024 dataset.
Negative regulators of DDX58/IFIH1 signaling Gene Set From Reactome Pathways 2024 proteins participating in the Negative regulators of DDX58/IFIH1 signaling pathway from the Reactome Pathways 2024 dataset.
IFIH1-related interferonopathy Gene Set From ClinVar Gene-Phenotype Associations 2025 genes associated with the IFIH1-related interferonopathy phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
IFIH1-related interferonopathy Gene Set From ClinVar Gene-Phenotype Associations 2025 genes associated with the IFIH1-related interferonopathy phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.