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IKBKE Geneinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009] |
IKBKE-AS1 GeneIKBKE antisense RNA 1 |
ikbke Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term ikbke in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
IKBKE Gene SetFrom Hub Proteins Protein-Protein Interactions interacting proteins for hub protein IKBKE from the curated Hub Proteins Protein-Protein Interactions dataset. |
IKBKE Gene SetFrom KEA Substrates of Kinases substrates of the kinase IKBKE from the curated KEA Substrates of Kinases dataset. |
IKBKE Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for IKBKE from the Pathway Commons Protein-Protein Interactions dataset. |
IKBKE Gene SetFrom PhosphoSitePlus Substrates of Kinases substrates of the kinase IKBKE from the curated PhosphoSitePlus Substrates of Kinases dataset. |
IKBKE Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the IKBKE gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |
TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1) Gene Setproteins in the TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1) protein complex from the CORUM Protein Complexes dataset. |
Suppressor of IKBKE 1 Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Suppressor of IKBKE 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Gene Setproteins participating in the Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) pathway from the Reactome Pathways 2024 dataset. |
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Gene Setproteins participating in the Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 pathway from the Reactome Pathways 2024 dataset. |