Name

IKBKE Gene

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]

IKBKE-AS1 Gene

IKBKE antisense RNA 1

ikbke Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ikbke in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

IKBKE Gene Set

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein IKBKE from the curated Hub Proteins Protein-Protein Interactions dataset.

IKBKE Gene Set

From KEA Substrates of Kinases

substrates of the kinase IKBKE from the curated KEA Substrates of Kinases dataset.

IKBKE Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for IKBKE from the Pathway Commons Protein-Protein Interactions dataset.

IKBKE Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase IKBKE from the curated PhosphoSitePlus Substrates of Kinases dataset.

IKBKE Gene Set

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the IKBKE gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1) Gene Set

From CORUM Protein Complexes

proteins in the TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1) protein complex from the CORUM Protein Complexes dataset.

Suppressor of IKBKE 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Suppressor of IKBKE 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Gene Set

From Reactome Pathways 2024

proteins participating in the Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) pathway from the Reactome Pathways 2024 dataset.

Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Gene Set

From Reactome Pathways 2024

proteins participating in the Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 pathway from the Reactome Pathways 2024 dataset.