Harmonizome 3.0

interleukin 4

The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury. In an allergic response, IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. This pro-inflammatory cytokine has been observed to be increased in COVID-19 (Coronavirus disease 2019) patients, but is not necessarily associated with severe COVID-19 pathology. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for IL4 from the MSigDB Cancer Gene Co-expression Modules dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for IL4 from the Pathway Commons Protein-Protein Interactions dataset.

From CORUM Protein Complexes

proteins in the IL4-IL4R complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the IL4-IL4R-IL2RG complex protein complex from the CORUM Protein Complexes dataset.

From PID Pathways

proteins participating in the IL4-mediated signaling events pathway from the PID Pathways dataset.

From WikiPathways Pathways 2024

proteins participating in the IL4 signaling pathway from the WikiPathways Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the LTC4-CYSLTR mediated IL4 production pathway from the Reactome Pathways 2024 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC10037107-JEM_20221755_TableS6.docx-0-IL4-WT-STAT6_targets_in_Jurkats_STAT6 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC10037107-JEM_20221755_TableS6.docx-0-IL4-WT-STAT6_targets_in_Jurkats_1_STAT6 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC10037107-JEM_20221755_TableS6.docx-0-IL4-WT-STAT6_targets_in_Jurkats_2_STAT6 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC10037107-JEM_20221755_TableS6.docx-0-IL4-WT-STAT6_targets_in_Jurkats_3_STAT6 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC10037107-JEM_20221755_TableS6.docx-0-IL4-p_E382Q-STAT6_targets_in_Jurkats_STAT6 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC10037107-JEM_20221755_TableS6.docx-0-IL4-p_E382Q-STAT6_targets_in_Jurkats_1_STAT6 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC10037107-JEM_20221755_TableS6.docx-0-IL4-p_E382Q-STAT6_targets_in_Jurkats_2_STAT6 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC10037107-JEM_20221755_TableS6.docx-0-IL4-p_E382Q-STAT6_targets_in_Jurkats_3_STAT6 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC10037107-JEM_20221755_TableS6.docx-0-IL4-p_D419G-STAT6_targets_in_Jurkats_STAT6 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC10037107-JEM_20221755_TableS6.docx-0-IL4-p_D419G-STAT6_targets_in_Jurkats_1_STAT6 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC10037107-JEM_20221755_TableS6.docx-0-IL4-p_D419G-STAT6_targets_in_Jurkats_2_STAT6 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC10037107-JEM_20221755_TableS6.docx-0-IL4-p_D419G-STAT6_targets_in_Jurkats_3_STAT6 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.