Harmonizome 3.0

lipoprotein, Lp(a)

The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term lpa in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for LPA from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the LPA gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From DGIdb Drug Targets 2026

interacting proteins for the LPA drug from theDGIdb Drug Targets 2026 dataset.

From GAD Gene-Disease Associations

genes associated with the disease reduced hdl cholesterol and lpa-i in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the anti-BrP-LPA ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the BrP-LPA ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the 2-oleoyl-LPA ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the syn-BrP-LPA ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the LPA(18:2(9Z,12Z)/0:0) metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the LPA(18:0/0:0) metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the LPA(P-16:0e/0:0) metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the LPA(16:0/0:0) metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the LPA(18:0e/0:0) metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the LPA(0:0/18:1(9Z)) metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the LPA(0:0/18:2(9Z,12Z)) metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the LPA(0:0/18:0) metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the LPA(0:0/16:0) metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the LPA(18:1(9Z)/0:0) metabolite from the curated HMDB Metabolites of Enzymes dataset.

From OMIM Gene-Disease Associations

genes associated with the [lpa deficiency, congenital] phenotype from the curated OMIM Gene-Disease Associations dataset.

From PID Pathways

proteins participating in the LPA receptor mediated events pathway from the PID Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Lysosphingolipid and LPA receptors pathway from the Reactome Pathways dataset.

From Reactome Pathways 2024

proteins participating in the Lysosphingolipid and LPA receptors pathway from the Reactome Pathways 2024 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the 2-OLEOYL-LPA drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the ANTI-BRP-LPA drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the BRP-LPA drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the SYN-BRP-LPA drug from theDGIdb Drug Targets 2026 dataset.