Harmonizome 3.0

mitogen-activated protein kinase kinase 1

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term map2k1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase MAP2K1 from the curated KEA Substrates of Kinases dataset.

From NURSA Protein-Protein Interactions

interacting proteins for MAP2K1 from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for MAP2K1 from the Pathway Commons Protein-Protein Interactions dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase MAP2K1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the MAP2K1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the MAP2K1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the RAF1-MAP2K1-YWHAE complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BRAF-MAP2K1-MAP2K2-YWHAE complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the MAP2K1-BRAF-RAF1-YWHAE-KSR1 complex protein complex from the CORUM Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL8445 (MAP2K1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the MAP2K1-related RASopathy phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.