Harmonizome 3.0

v-mos Moloney murine sarcoma viral oncogene homolog

MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]

FBJ murine osteosarcoma viral oncogene homolog

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]

FBJ murine osteosarcoma viral oncogene homolog B

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Friend-murine leukemia virus integration site 3 homolog

Friend-murine leukemia virus integration site 1 homolog

v-akt murine thymoma viral oncogene homolog 1

This gene encodes one of the three members of the human AKT serine-threonine protein kinase family which are often referred to as protein kinase B alpha, beta, and gamma. These highly similar AKT proteins all have an N-terminal pleckstrin homology domain, a serine/threonine-specific kinase domain and a C-terminal regulatory domain. These proteins are phosphorylated by phosphoinositide 3-kinase (PI3K). AKT/PI3K forms a key component of many signalling pathways that involve the binding of membrane-bound ligands such as receptor tyrosine kinases, G-protein coupled receptors, and integrin-linked kinase. These AKT proteins therefore regulate a wide variety of cellular functions including cell proliferation, survival, metabolism, and angiogenesis in both normal and malignant cells. AKT proteins are recruited to the cell membrane by phosphatidylinositol 3,4,5-trisphosphate (PIP3) after phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) by PI3K. Subsequent phosphorylation of both threonine residue 308 and serine residue 473 is required for full activation of the AKT1 protein encoded by this gene. Phosphorylation of additional residues also occurs, for example, in response to insulin growth factor-1 and epidermal growth factor. Protein phosphatases act as negative regulators of AKT proteins by dephosphorylating AKT or PIP3. The PI3K/AKT signalling pathway is crucial for tumor cell survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating AKT1 which then phosphorylates and inactivates components of the apoptotic machinery. AKT proteins also participate in the mammalian target of rapamycin (mTOR) signalling pathway which controls the assembly of the eukaryotic translation initiation factor 4F (eIF4E) complex and this pathway, in addition to responding to extracellular signals from growth factors and cytokines, is disregulated in many cancers. Mutations in this gene are associated with multiple types of cancer and excessive tissue growth including Proteus syndrome and Cowden syndrome 6, and breast, colorectal, and ovarian cancers. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2020]

v-akt murine thymoma viral oncogene homolog 2

This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways. The gene serves as an oncogene in the tumorigenesis of cancer cells For example, its overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins, and has also been implicated in insulin signaling. [provided by RefSeq, Nov 2019]

v-akt murine thymoma viral oncogene homolog 3

The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed

This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the ubiquitin-like protein fubi at the N terminus and ribosomal protein S30 at the C terminus. It has been proposed that the fusion protein is post-translationally processed to generate free fubi and free ribosomal protein S30. Fubi is a member of the ubiquitin family, and ribosomal protein S30 belongs to the S30E family of ribosomal proteins. Whereas the function of fubi is currently unknown, ribosomal protein S30 is a component of the 40S subunit of the cytoplasmic ribosome and displays antimicrobial activity. Pseudogenes derived from this gene are present in the genome. Similar to ribosomal protein S30, ribosomal proteins S27a and L40 are synthesized as fusion proteins with ubiquitin. [provided by RefSeq, Nov 2014]

murine retrovirus integration site 1 homolog

This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011]

Moloney murine leukemia virus (MoMuLV) integration site 2 homolog

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Murine polyomavirus (strain 3) from the Virus MINT Protein-Virus Interactions dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term murine in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the E2A_KO_GSE43224_679_mouse_DN2 cells from WT and E2A-deficient murine fetal thymi gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term murine in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Murine adenovirus 1 from the Virus MINT Protein-Virus Interactions dataset.

From GAD Gene-Disease Associations

genes associated with the disease cytomegalovirus infections; epstein-barr virus infections; polyomavirus infections; recurrence; tumor virus infections in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term polyomavirus in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus JC polyomavirus from the Virus MINT Protein-Virus Interactions dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Polyomavirus-Associated Nephropathy in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Merkel Cell Polyomavirus Infection in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From DISEASES Text-mining Gene-Disease Association Evidence Scores 2025

genes co-occuring with the disease Polyomavirus-associated nephropathy in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Anti-polyomavirus 2 IgG seropositivity phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Polyomavirus 2 JC VP1 antibody levels phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Anti-Merkel cell polyomavirus IgG seropositivity phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Merkel cell polyomavirus VP1 antibody levels phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the BK polyomavirus VP1 antibody levels phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term strain in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Sendai virus (strain Fushimi) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Fowl adenovirus 1 (strain CELO / Phelps) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Cottontail rabbit papillomavirus (strain Kansas) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Epstein-Barr virus (strain GD1) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Epstein-Barr virus (strain B95-8) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Saimiriine herpesvirus 2 (strain 11) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Rous sarcoma virus (strain Schmidt-Ruppin A) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Influenza A virus (strain A/Puerto Rico/8/34 H1N1) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Poliovirus type 1 (strain Sabin) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Influenza A virus (strain A/Aichi/2/1968 H3N2) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Human herpesvirus 1 (strain Patton) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Hepatitis E virus (strain Burma) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Hepatitis E virus (strain Mexico) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Vaccinia virus (strain Copenhagen) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Avian sarcoma virus (strain PR2257) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Human herpesvirus 1 (strain 17) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Vaccinia virus (strain Western Reserve / WR) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Saimiriine herpesvirus 2 (strain 488) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Vaccinia virus (strain L-IVP) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Simian virus 5 (strain W3) from the Virus MINT Protein-Virus Interactions dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Left ventricular global radial strain phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Left ventricular global circumferential strain (MTAG) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Left ventricular global radial strain (MTAG) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Left ventricular global longitudinal strain (MTAG) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Left ventricular global circumferential strain phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Left ventricular global longitudinal strain phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the COMMENSAL BACTERIAL STRAIN FORMULATION VE800 drug from theDGIdb Drug Targets 2026 dataset.