PCSK9

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Results for "PCSK9": 1 gene, 11 gene sets

Name
PCSK9 Gene proprotein convertase subtilisin/kexin type 9 This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
pcsk9 Gene Set From GeneRIF Biological Term Annotations genes co-occuring with the biological term pcsk9 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
PCSK9 Gene Set From Pathway Commons Protein-Protein Interactions interacting proteins for PCSK9 from the Pathway Commons Protein-Protein Interactions dataset.
PCSK9 Gene Set From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the PCSK9 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
PCSK9 Gene Set From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the PCSK9 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.
PCSK9-mediated LDLR degradation(Homo sapiens) Gene Set From WikiPathways Pathways 2014 proteins participating in the PCSK9-mediated LDLR degradation(Homo sapiens) pathway from the WikiPathways Pathways 2014 dataset.
PCSK9 mediated LDL receptor degradation Gene Set From WikiPathways Pathways 2024 proteins participating in the PCSK9 mediated LDL receptor degradation pathway from the WikiPathways Pathways 2024 dataset.
PCSK9-AnxA2 complex Gene Set From COMPARTMENTS Curated Protein Localization Evidence Scores 2025 proteins localized to the PCSK9-AnxA2 complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
PCSK9-LDLR complex Gene Set From COMPARTMENTS Curated Protein Localization Evidence Scores 2025 proteins localized to the PCSK9-LDLR complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
PCSK9-LDLR complex Gene Set From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 proteins co-occuring with the PCSK9-LDLR complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
PCSK9-AnxA2 complex Gene Set From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 proteins co-occuring with the PCSK9-AnxA2 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
Response to simvastatin treatment (PCSK9 protein level change) Gene Set From GWAS Catalog SNP-Phenotype Associations 2025 genes associated with the Response to simvastatin treatment (PCSK9 protein level change) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.