Harmonizome 3.0

From Pathway Commons

Protein-protein interactions from low-throughput or high-throughput studies aggregated by Pathway Commons from the following databases: Reactome, NCI Pathways, PhosphoSite, HumanCyc, HPRD, PANTHER, DIP, BioGRID, IntAct, BIND, Transfac, MiRTarBase, Drugbank, Recon X, Comparative Toxicogenomics Database, and KEGG

From Pathway Figure Optical Character Recognition

Sets of genes/proteins extracted from pathway figures in research publications using optical character recognition

From Pathway Figure Optical Character Recognition

Sets of genes/proteins extracted from pathway figures in research publications using optical character recognition, updated for 2024

From Gene Expression Omnibus

mRNA expression profiles for cell lines or tissues following kinase perturbation (inhibition, activation, knockdown, knockout, over-expression, mutation)

From LINCS Kinativ

Percent inhibition of kinases by small molecules measured in cell lysates

From LINCS KinomeScan

Kinase inhibitor targets from percent inhibition of kinases by small molecules measured using purified kinases

From Kinase Library

A phosphoproteomics atlas detailing phosphorylation of protein substrates by 303 serine/threonine kinases in the human kinome.

From Kinase Library

A phosphoproteomics atlas detailing phosphorylation of protein substrates by 93 canonical and non-canonical tyrosine kinases in the human kinome.

From Kinase Enrichment Analysis

Protein substrates of kinases from published low-throughput and high-throughput phosphoproteomics studies

From Pathway Interaction Database

Sets of proteins participating in pathways from PID