Harmonizome 3.0

protein inhibitor of activated STAT, 1

This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pias1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for PIAS1 from the Pathway Commons Protein-Protein Interactions dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the PIAS1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the Klf5-Pias1 complex protein complex from the CORUM Protein Complexes dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the E3 SUMO-protein ligase PIAS1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From NURSA Protein Complexes

proteins in the SC-14016 (PIAS1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From ChEA Transcription Factor Targets 2022

target genes of the PIAS1-25552417-VCAP-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.