Harmonizome 3.0

proopiomelanocortin

This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jan 2016]

chromosome 20 open reading frame 141

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

RNA, 5S ribosomal pseudogene 141

zinc finger protein 141

The protein encoded by this gene is a zinc finger protein that may be a tumor suppressor. Defects in this gene have been associated with autosomal recessive postaxial polydactyly type A. [provided by RefSeq, Jan 2017]

G protein-coupled receptor 141 pseudogene

G protein-coupled receptor 141

GPR141 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]

ring finger protein 141

The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. Abundant expression of this gene was found in the testicular tissue of fertile men, but was not detected in azoospermic patients. Studies of the mouse counterpart suggest that this gene may function as a testis specific transcription factor during spermatogenesis. [provided by RefSeq, Jul 2008]

chromosome 1 open reading frame 141

coiled-coil domain containing 141

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in brain development. Predicted to act upstream of or within centrosome localization and cerebral cortex radially oriented cell migration. Predicted to be located in centrosome and cytoplasm. [provided by Alliance of Genome Resources, Mar 2025]

transmembrane protein 141

Located in mitochondrion. [provided by Alliance of Genome Resources, Mar 2025]

microRNA 141

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

chromosome 6 open reading frame 141

Predicted to act upstream of or within blastocyst hatching. [provided by Alliance of Genome Resources, Mar 2025]

cilia and flagella associated protein 141

Predicted to be involved in flagellated sperm motility. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Mar 2025]

From DGIdb Drug Targets 2026

interacting proteins for the POMC (141-162) drug from theDGIdb Drug Targets 2026 dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pomc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Guide to Pharmacology Protein Ligands of Receptors

receptors of the POMC ligand (protein) from the curated Guide to Pharmacology Protein Ligands of Receptors dataset.

From OMIM Gene-Disease Associations

genes associated with the obesity, adrenal insufficiency, and red hair due to pomc deficiency phenotype from the curated OMIM Gene-Disease Associations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for POMC from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the POMC gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the POMC gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the chlorpropamide-141 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical L-826,141 from the curated CTD Gene-Chemical Interactions dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the KB-141 ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From MiRTarBase microRNA Targets

target genes of the hsa-miR-141-3p microRNA in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.

From TargetScan Predicted Conserved microRNA Targets

target genes of the hsa-miR-141 microRNA predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.

From TargetScan Predicted Nonconserved microRNA Targets

target genes of the hsa-miR-141 microRNA predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.

From HuBMAP ASCT+B Annotations

biomarker genes for the Brain_CT2_DLIT 141 cell type from the HuBMAP ASCT+B dataset.

From HuBMAP ASCT+B Augmented with RNA-seq Coexpression

biomarker genes for the Brain_CT2_DLIT 141 cell type from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset.

From DGIdb Drug Targets 2026

interacting proteins for the KB-141 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the NANOPARTICLE SN-38-ENCAPSULATED MICELLE FORMULATION IT-141 drug from theDGIdb Drug Targets 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC4521181-oncsis201520x8.pdf-141-ZGPAT_ZGPAT transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC3527296-1742-2094-9-141-S1.pdf-11-MAFB_MAFB transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC9691391-7945884.f3.pdf-141-ENSG00000198597_ZNF536 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11481653-mmc33.pdf-141-CEBPD_CEBPD transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11588066-pnas.2410331121.sapp.pdf-141-FOXO1_FOXO1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11665843-SYB2-18-218-s001.pdf-141-ZBTB10_ZBTB10 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC12005818-ADVS-12-2413491-s001.pdf-141-STAT6_STAT6 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.