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PAPSS1 Gene3'-phosphoadenosine 5'-phosphosulfate synthase 1 Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008] |
PAPSS2 Gene3'-phosphoadenosine 5'-phosphosulfate synthase 2 Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
Phosphoadenosine Phosphosulfate Gene SetFrom CTD Gene-Chemical Interactions genes/proteins interacting with the chemical Phosphoadenosine Phosphosulfate from the curated CTD Gene-Chemical Interactions dataset. |
Phosphoadenosine phosphosulfate Gene SetFrom HMDB Metabolites of Enzymes interacting proteins for the Phosphoadenosine phosphosulfate metabolite from the curated HMDB Metabolites of Enzymes dataset. |
3'-phosphoadenosine 5'-phosphosulfate biosynthetic process Gene SetFrom GO Biological Process Annotations 2015 genes participating in the 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process biological process from the curated GO Biological Process Annotations 2015 dataset. |
3'-phosphoadenosine 5'-phosphosulfate transport Gene SetFrom GO Biological Process Annotations 2015 genes participating in the 3'-phosphoadenosine 5'-phosphosulfate transport biological process from the curated GO Biological Process Annotations 2015 dataset. |
3'-phosphoadenosine 5'-phosphosulfate metabolic process Gene SetFrom GO Biological Process Annotations 2015 genes participating in the 3'-phosphoadenosine 5'-phosphosulfate metabolic process biological process from the curated GO Biological Process Annotations 2015 dataset. |
3'-phosphoadenosine 5'-phosphosulfate binding Gene SetFrom GO Molecular Function Annotations 2015 genes performing the 3'-phosphoadenosine 5'-phosphosulfate binding molecular function from the curated GO Molecular Function Annotations 2015 dataset. |
3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity Gene SetFrom GO Molecular Function Annotations 2015 genes performing the 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations 2015 dataset. |
3'-phosphoadenosine 5'-phosphosulfate metabolic process Gene SetFrom GO Biological Process Annotations 2023 genes participating in the 3'-phosphoadenosine 5'-phosphosulfate metabolic process biological process from the curated GO Biological Process Annotations 2023 dataset. |
3'-phosphoadenosine 5'-phosphosulfate biosynthetic process Gene SetFrom GO Biological Process Annotations 2023 genes participating in the 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process biological process from the curated GO Biological Process Annotations 2023 dataset. |
3'-phosphoadenosine 5'-phosphosulfate transport Gene SetFrom GO Biological Process Annotations 2023 genes participating in the 3'-phosphoadenosine 5'-phosphosulfate transport biological process from the curated GO Biological Process Annotations 2023 dataset. |
3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity Gene SetFrom GO Molecular Function Annotations 2023 genes performing the 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations 2023 dataset. |
3'-phosphoadenosine 5'-phosphosulfate metabolic process Gene SetFrom GO Biological Process Annotations 2025 genes participating in the 3'-phosphoadenosine 5'-phosphosulfate metabolic process biological process from the curated GO Biological Process Annotations 2025 dataset. |
3'-phosphoadenosine 5'-phosphosulfate biosynthetic process Gene SetFrom GO Biological Process Annotations 2025 genes participating in the 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process biological process from the curated GO Biological Process Annotations 2025 dataset. |
3'-phosphoadenosine 5'-phosphosulfate transport Gene SetFrom GO Biological Process Annotations 2025 genes participating in the 3'-phosphoadenosine 5'-phosphosulfate transport biological process from the curated GO Biological Process Annotations 2025 dataset. |
3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity Gene SetFrom GO Molecular Function Annotations 2025 genes performing the 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations 2025 dataset. |
Phosphoadenosine phosphosulphate reductase Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Phosphoadenosine phosphosulphate reductase protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Adenosine-5'-Phosphosulfate Gene Setinteracting proteins for the Adenosine-5'-Phosphosulfate drug from the curated DrugBank Drug Targets dataset. |
Adenosine phosphosulfate Gene SetFrom HMDB Metabolites of Enzymes interacting proteins for the Adenosine phosphosulfate metabolite from the curated HMDB Metabolites of Enzymes dataset. |
