Harmonizome 3.0

RAN, member RAS oncogene family

RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ran in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for RAN from the MSigDB Cancer Gene Co-expression Modules dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for RAN from the Pathway Commons Protein-Protein Interactions dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the RAN gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From Biocarta Pathways

proteins participating in the role of ran in mitotic spindle regulation pathway from the Biocarta Pathways dataset.

From Biocarta Pathways

proteins participating in the cycling of ran in nucleocytoplasmic transport pathway from the Biocarta Pathways dataset.

From CORUM Protein Complexes

proteins in the CRM1-RAN-PHAX-CBC complex (cap binding complex) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the RANBP1-RAN-KPNB1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the IPO13-RAN-EIF1AX complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the TNPO2-RAN-NXF1 complex protein complex from the CORUM Protein Complexes dataset.

From GO Molecular Function Annotations 2015

genes performing the ran guanyl-nucleotide exchange factor activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From GO Molecular Function Annotations 2015

genes performing the ran gtpase binding molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the 5-methyl-​5-(5-meth​ylthiophe​n-3-yl)-4​-oxo-4 5-​dihydrofu​ran-2-car​boxylic a​cid ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Ran-interacting Mog1 protein protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Ran GTPase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Uncharacterised conserved protein UCP037956, zinc finger Ran-binding protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Ran binding domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Ran GTPase-activating protein protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Ran-GTPase activating protein 1, C-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From GO Biological Process Annotations 2023

genes participating in the Ran protein signal transduction biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the regulation of microtubule nucleation by Ran protein signal transduction biological process from the curated GO Biological Process Annotations 2023 dataset.