Harmonizome 3.0

retinoid X receptor, gamma

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]

retinoic acid receptor, alpha

This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]

RARA antisense RNA 1

PML-RARA regulated adaptor molecule 1

The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008]

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the RARA::RXRG transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for RXRG from the Pathway Commons Protein-Protein Interactions dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the RXRG transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the RXRG gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the CBP-RARA-RXRA-DNA complex, ligand stimulated protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term rara in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From OMIM Gene-Disease Associations

genes associated with the leukemia, acute promyelocytic, pml/rara type phenotype from the curated OMIM Gene-Disease Associations dataset.

From OMIM Gene-Disease Associations

genes associated with the leukemia, acute promyelocytic, stat5b/rara type phenotype from the curated OMIM Gene-Disease Associations dataset.

From OMIM Gene-Disease Associations

genes associated with the leukemia, acute promyelocytic, npm/rara type phenotype from the curated OMIM Gene-Disease Associations dataset.

From OMIM Gene-Disease Associations

genes associated with the leukemia, acute promyelocytic, pl2f/rara type phenotype from the curated OMIM Gene-Disease Associations dataset.

From OMIM Gene-Disease Associations

genes associated with the leukemia, acute promyelocytic, numa/rara type phenotype from the curated OMIM Gene-Disease Associations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for RARA from the Pathway Commons Protein-Protein Interactions dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Childhood Acute Promyelocytic Leukemia With Pml-Rara in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Adult Acute Promyelocytic Leukemia With Pml-Rara in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From ChEA Transcription Factor Targets 2022

target genes of the RARA-24833708-LIVER-MOUSE transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the RARA gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From DISEASES Text-mining Gene-Disease Association Evidence Scores 2025

genes co-occuring with the disease Acute promyelocytic leukemia with PML-RARA in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the RARA transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the RARA::RXRA transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC10866659-jci-134-176311-s178.xlsx-S1_TurboID_vs_PML-RARA-gene_RARA transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC12612227-41523_2025_836_MOESM1_ESM.pdf-112-RARA-AS1_RARA transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the RARA gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.