Harmonizome 3.0

E1A binding protein p300

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]

EP300 antisense RNA 1

EP300 interacting inhibitor of differentiation 2B

Enables identical protein binding activity. Involved in negative regulation of DNA-templated transcription and negative regulation of myoblast differentiation. Located in nucleus. [provided by Alliance of Genome Resources, Mar 2025]

EP300 interacting inhibitor of differentiation 2

Enables SMAD binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and transforming growth factor beta receptor complex assembly. Located in nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]

EP300 interacting inhibitor of differentiation 3

Predicted to be involved in DNA repair. Located in nucleolus and nucleoplasm. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Mar 2025]

EP300 interacting inhibitor of differentiation 1

Enables histone acetyltransferase binding activity. Involved in cell differentiation and negative regulation of DNA-templated transcription. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasmic ribonucleoprotein granule and nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]

From NURSA Protein Complexes

proteins in the SC-585 (EP300) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the EP300-20729851-FORBRAIN_MIDBRAIN_LIMB_HEART-MOUSE transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the EP300-21415370-HL-1-MOUSE transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Targets

target genes of the EP300 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

From CORUM Protein Complexes

proteins in the TCF4-CTNNB1-EP300 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the EGR-EP300 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the TCF4-CTNNB1-SUMO1-EP300-HADAC6 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Src1-Ep300-Crebbp complex protein complex from the CORUM Protein Complexes dataset.

From ENCODE Transcription Factor Targets

target genes of the EP300 transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ep300 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein EP300 from the curated Hub Proteins Protein-Protein Interactions dataset.

From NURSA Protein Complexes

proteins in the BL442 (EP300) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL443 (EP300) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the SC-584 (EP300) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein-Protein Interactions

interacting proteins for EP300 from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for EP300 from the Pathway Commons Protein-Protein Interactions dataset.

From ChEA Transcription Factor Targets 2022

target genes of the EP300-21415370-HL-1-MOUSE transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the EP300-20729851-FORBRAIN-MIDBRAIN-LIMB-HEART-MOUSE transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the EP300 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the Rubinstein-Taybi syndrome due to EP300 haploinsufficiency phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the EP300 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.