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SEMA3A Genesema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq, Jul 2008] |
sema3a Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term sema3a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
SEMA3A Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for SEMA3A from the Pathway Commons Protein-Protein Interactions dataset. |
SEMA3A Gene SetFrom LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the SEMA3A gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. |
PlexinA1-NRP1-SEMA3A complex Gene Setproteins in the PlexinA1-NRP1-SEMA3A complex protein complex from the CORUM Protein Complexes dataset. |
CRMP-MICAL-PlexinA1 complex, induced by SEMA3A Gene Setproteins in the CRMP-MICAL-PlexinA1 complex, induced by SEMA3A protein complex from the CORUM Protein Complexes dataset. |
CRMPs in Sema3A signaling Gene Setproteins participating in the CRMPs in Sema3A signaling pathway from the Reactome Pathways dataset. |
Sema3A PAK dependent Axon repulsion Gene Setproteins participating in the Sema3A PAK dependent Axon repulsion pathway from the Reactome Pathways dataset. |
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Gene Setproteins participating in the SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion pathway from the Reactome Pathways dataset. |
CRMPs in Sema3A signaling Gene Setproteins participating in the CRMPs in Sema3A signaling pathway from the Reactome Pathways 2024 dataset. |
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Gene Setproteins participating in the SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion pathway from the Reactome Pathways 2024 dataset. |
Sema3A PAK dependent Axon repulsion Gene Setproteins participating in the Sema3A PAK dependent Axon repulsion pathway from the Reactome Pathways 2024 dataset. |