Harmonizome 3.0

son of sevenless homolog 1 (Drosophila)

This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]

SOS1 intronic transcript 1

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sos1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for SOS1 from the Pathway Commons Protein-Protein Interactions dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the SOS1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the Sos1-Abi1-Eps8 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the PLC-gamma-1-SLP-76-SOS1-LAT complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BCR-ABL (p210 fusion protein)-GRB2-SOS1 complex protein complex from the CORUM Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL7507 (SOS1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From DGIdb Drug Targets 2026

interacting proteins for the SOS1 PROTAC 9D drug from theDGIdb Drug Targets 2026 dataset.