Name

DIABLO Gene

diablo, IAP-binding mitochondrial protein

This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

Smac/DIABLO-like Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Smac/DIABLO-like protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Smac/DIABLO protein Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Smac/DIABLO protein protein domain from the InterPro Predicted Protein Domain Annotations dataset.

SMAC (DIABLO) binds to IAPs Gene Set

From Reactome Pathways 2024

proteins participating in the SMAC (DIABLO) binds to IAPs pathway from the Reactome Pathways 2024 dataset.

SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Gene Set

From Reactome Pathways 2024

proteins participating in the SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes pathway from the Reactome Pathways 2024 dataset.

diablo Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term diablo in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

DIABLO Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for DIABLO from the Pathway Commons Protein-Protein Interactions dataset.

DIABLO Gene Set

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the DIABLO gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

smac Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term smac in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SMAC-mediated dissociation of IAP:caspase complexes Gene Set

From Reactome Pathways 2014

proteins participating in the SMAC-mediated dissociation of IAP:caspase complexes pathway from the Reactome Pathways dataset.

SMAC binds to IAPs Gene Set

From Reactome Pathways 2014

proteins participating in the SMAC binds to IAPs pathway from the Reactome Pathways dataset.

SMAC-mediated apoptotic response Gene Set

From Reactome Pathways 2014

proteins participating in the SMAC-mediated apoptotic response pathway from the Reactome Pathways dataset.

SMAC, XIAP-regulated apoptotic response Gene Set

From Reactome Pathways 2024

proteins participating in the SMAC, XIAP-regulated apoptotic response pathway from the Reactome Pathways 2024 dataset.

SMAC MIMETIC GDC-0917 Gene Set

From DGIdb Drug Targets 2026

interacting proteins for the SMAC MIMETIC GDC-0917 drug from theDGIdb Drug Targets 2026 dataset.