Harmonizome 3.0

Pim-2 proto-oncogene, serine/threonine kinase

This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009]

Pim-3 proto-oncogene, serine/threonine kinase

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a selective advantage in tumorigenesis. [provided by RefSeq, Jun 2012]

Pim-1 proto-oncogene, serine/threonine kinase

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]

From DeepCoverMOA Drug Mechanisms of Action

proteins with high or low expression in TCS PIM-1 1 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pim in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Serine/threonine-protein kinase pim-1/2/3 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From DGIdb Drug Targets 2026

interacting proteins for the PIM KINASE INHIBITOR LGH447 drug from theDGIdb Drug Targets 2026 dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tcs in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the TCS 2510 ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the TCS-OX2-29 ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From DeepCoverMOA Drug Mechanisms of Action

proteins with high or low expression in TCS ERK 11e relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

From DeepCoverMOA Drug Mechanisms of Action

proteins with high or low expression in TCS-OX2-29 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

From DeepCoverMOA Drug Mechanisms of Action

proteins with high or low expression in TCS 1102 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

From LINCS L1000 CMAP Chemical Perturbation Consensus Signatures

genes differentially expressed following the TCS-2002 small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

From DGIdb Drug Targets 2026

interacting proteins for the TCS 1102 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the [3H]-TCS 1102 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the TCS-OX2-29 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the TCS 2510 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the TCS 5861528 drug from theDGIdb Drug Targets 2026 dataset.