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TLR6 Genetoll-like receptor 6 The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011] |
tlr6 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term tlr6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
TLR6 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for TLR6 from the Pathway Commons Protein-Protein Interactions dataset. |
TLR6 Gene SetFrom LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the TLR6 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. |
toll-like receptor tlr6:tlr2 signaling pathway Gene SetFrom GO Biological Process Annotations 2015 genes participating in the toll-like receptor tlr6:tlr2 signaling pathway biological process from the curated GO Biological Process Annotations 2015 dataset. |
Toll Like Receptor TLR6:TLR2 Cascade Gene Setproteins participating in the Toll Like Receptor TLR6:TLR2 Cascade pathway from the Reactome Pathways dataset. |
toll-like receptor TLR6:TLR2 signaling pathway Gene SetFrom GO Biological Process Annotations 2023 genes participating in the toll-like receptor TLR6:TLR2 signaling pathway biological process from the curated GO Biological Process Annotations 2023 dataset. |
Toll Like Receptor TLR6:TLR2 Cascade Gene Setproteins participating in the Toll Like Receptor TLR6:TLR2 Cascade pathway from the Reactome Pathways 2024 dataset. |
toll-like receptor TLR6:TLR2 signaling pathway Gene SetFrom GO Biological Process Annotations 2025 genes participating in the toll-like receptor TLR6:TLR2 signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset. |