Name

TRAF3 Gene

TNF receptor-associated factor 3

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. The protein also plays a role in the regulation of antiviral response. Mutations in this are associated with Encephalopathy, acute, infection-induced, herpes-specific 5. [provided by RefSeq, Jul 2020]

traf3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term traf3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

TRAF3 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for TRAF3 from the Pathway Commons Protein-Protein Interactions dataset.

TRAF3 Gene Set

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the TRAF3 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

TANK-TRAF2-TRAF3 complex Gene Set

From CORUM Protein Complexes

proteins in the TANK-TRAF2-TRAF3 complex protein complex from the CORUM Protein Complexes dataset.

TRAF3-interacting protein 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the TRAF3-interacting protein 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

TRAF3-dependent IRF activation pathway Gene Set

From Reactome Pathways 2014

proteins participating in the TRAF3-dependent IRF activation pathway pathway from the Reactome Pathways dataset.

TRAF3 deficiency - HSE Gene Set

From Reactome Pathways 2024

proteins participating in the TRAF3 deficiency - HSE pathway from the Reactome Pathways 2024 dataset.

TRAF3-dependent IRF activation pathway Gene Set

From Reactome Pathways 2024

proteins participating in the TRAF3-dependent IRF activation pathway pathway from the Reactome Pathways 2024 dataset.