Harmonizome 3.0

ubiquitin-like modifier activating enzyme 2

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term uba2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for UBA2 from the Pathway Commons Protein-Protein Interactions dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the UBA2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the SUA1-UBA2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SUMO1-SUA1-UBA2 complex protein complex from the CORUM Protein Complexes dataset.

From Reactome Pathways 2014

proteins participating in the SUMO is conjugated to E1 (UBA2:SAE1) pathway from the Reactome Pathways dataset.

From Reactome Pathways 2024

proteins participating in the SUMO is conjugated to E1 (UBA2:SAE1) pathway from the Reactome Pathways 2024 dataset.