Harmonizome 3.0

valosin containing protein

This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B pathway. This protein forms a homohexameric complex that interacts with a variety of cofactors and extracts ubiquitinated proteins from lipid membranes or protein complexes. Mutations in this gene cause IBMPFD (inclusion body myopathy with paget disease of bone and frontotemporal dementia), ALS (amyotrophic lateral sclerosis) and Charcot-Marie-Tooth disease in human patients. [provided by RefSeq, Aug 2017]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vcp in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From NURSA Protein-Protein Interactions

interacting proteins for VCP from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for VCP from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the VCP gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the VCP gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the Membrane protein complex (DERL1, SELS, VCP) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the p97/VCP homohexamer complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BRCA1-VCP complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SVIP-p97/VCP-DERL1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the p97/VCP-VIMP-DERL1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the p97/VCP-VIMP-DERL1-DERL2-HRD1-SEL1L complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Membrane protein complex (VCP, UFD1L, SEC61B) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the p97/VCP-VIMP-DERL2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the gp78-p97/VCP-DERL1 complex protein complex from the CORUM Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL2519 (VCP) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From GO Biological Process Annotations 2023

genes participating in the negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2025

genes participating in the negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly biological process from the curated GO Biological Process Annotations 2025 dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores 2025

proteins localized to the VCP-NPL4-UFD1 AAA ATPase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores 2025

proteins localized to the VCP-NSFL1C complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the VCP-NSFL1C complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the VCP-NPL4-UFD1 AAA ATPase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the Childhood Onset VCP-related Neurodevelopmental Disorder phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.