Name

NRXN3 Gene

neurexin 3

This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012]

NRXN2 Gene

neurexin 2

This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010]

NRXN1 Gene

neurexin 1

This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. [provided by RefSeq, Aug 2016]

neurexin clustering Gene Set

From GO Biological Process Annotations 2015

genes participating in the neurexin clustering biological process from the curated GO Biological Process Annotations 2015 dataset.

neurexin clustering involved in presynaptic membrane assembly Gene Set

From GO Biological Process Annotations 2023

genes participating in the neurexin clustering involved in presynaptic membrane assembly biological process from the curated GO Biological Process Annotations 2023 dataset.

neurexin clustering involved in presynaptic membrane assembly Gene Set

From GO Biological Process Annotations 2025

genes participating in the neurexin clustering involved in presynaptic membrane assembly biological process from the curated GO Biological Process Annotations 2025 dataset.

neurexin Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term neurexin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

neurexin family protein binding Gene Set

From GO Molecular Function Annotations 2015

genes performing the neurexin family protein binding molecular function from the curated GO Molecular Function Annotations 2015 dataset.

Syndecan/Neurexin domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Syndecan/Neurexin domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Neurexin-3 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Neurexin-3 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Neurexin-2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Neurexin-2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Neurexin-1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Neurexin-1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Neurexin/syndecan/glycophorin C Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Neurexin/syndecan/glycophorin C protein domain from the InterPro Predicted Protein Domain Annotations dataset.

neurexin family protein binding Gene Set

From GO Molecular Function Annotations 2023

genes performing the neurexin family protein binding molecular function from the curated GO Molecular Function Annotations 2023 dataset.

neurexin family protein binding Gene Set

From GO Molecular Function Annotations 2025

genes performing the neurexin family protein binding molecular function from the curated GO Molecular Function Annotations 2025 dataset.

clustering Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term clustering in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

postsynaptic density protein 95 clustering Gene Set

From GO Biological Process Annotations 2015

genes participating in the postsynaptic density protein 95 clustering biological process from the curated GO Biological Process Annotations 2015 dataset.

n-methyl-d-aspartate receptor clustering Gene Set

From GO Biological Process Annotations 2015

genes participating in the n-methyl-d-aspartate receptor clustering biological process from the curated GO Biological Process Annotations 2015 dataset.

skeletal muscle acetylcholine-gated channel clustering Gene Set

From GO Biological Process Annotations 2015

genes participating in the skeletal muscle acetylcholine-gated channel clustering biological process from the curated GO Biological Process Annotations 2015 dataset.

neurotransmitter-gated ion channel clustering Gene Set

From GO Biological Process Annotations 2015

genes participating in the neurotransmitter-gated ion channel clustering biological process from the curated GO Biological Process Annotations 2015 dataset.

neuroligin clustering Gene Set

From GO Biological Process Annotations 2015

genes participating in the neuroligin clustering biological process from the curated GO Biological Process Annotations 2015 dataset.

receptor clustering Gene Set

From GO Biological Process Annotations 2015

genes participating in the receptor clustering biological process from the curated GO Biological Process Annotations 2015 dataset.

meiotic telomere clustering Gene Set

From GO Biological Process Annotations 2015

genes participating in the meiotic telomere clustering biological process from the curated GO Biological Process Annotations 2015 dataset.

glycine receptor clustering Gene Set

From GO Biological Process Annotations 2015

genes participating in the glycine receptor clustering biological process from the curated GO Biological Process Annotations 2015 dataset.

signal clustering Gene Set

From GO Biological Process Annotations 2015

genes participating in the signal clustering biological process from the curated GO Biological Process Annotations 2015 dataset.

neuronal ion channel clustering Gene Set

From GO Biological Process Annotations 2015

genes participating in the neuronal ion channel clustering biological process from the curated GO Biological Process Annotations 2015 dataset.

guanylate kinase-associated protein clustering Gene Set

From GO Biological Process Annotations 2015

genes participating in the guanylate kinase-associated protein clustering biological process from the curated GO Biological Process Annotations 2015 dataset.

ciliary receptor clustering involved in smoothened signaling pathway Gene Set

From GO Biological Process Annotations 2015

genes participating in the ciliary receptor clustering involved in smoothened signaling pathway biological process from the curated GO Biological Process Annotations 2015 dataset.

alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering Gene Set

From GO Biological Process Annotations 2015

genes participating in the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering biological process from the curated GO Biological Process Annotations 2015 dataset.

synaptic vesicle clustering Gene Set

From GO Biological Process Annotations 2015

genes participating in the synaptic vesicle clustering biological process from the curated GO Biological Process Annotations 2015 dataset.

regulation of synaptic vesicle clustering Gene Set

From GO Biological Process Annotations 2015

genes participating in the regulation of synaptic vesicle clustering biological process from the curated GO Biological Process Annotations 2015 dataset.

regulation of postsynaptic density protein 95 clustering Gene Set

From GO Biological Process Annotations 2015

genes participating in the regulation of postsynaptic density protein 95 clustering biological process from the curated GO Biological Process Annotations 2015 dataset.

gephyrin clustering Gene Set

From GO Biological Process Annotations 2015

genes participating in the gephyrin clustering biological process from the curated GO Biological Process Annotations 2015 dataset.

clustering of voltage-gated sodium channels Gene Set

From GO Biological Process Annotations 2015

genes participating in the clustering of voltage-gated sodium channels biological process from the curated GO Biological Process Annotations 2015 dataset.

clustering of voltage-gated potassium channels Gene Set

From GO Biological Process Annotations 2015

genes participating in the clustering of voltage-gated potassium channels biological process from the curated GO Biological Process Annotations 2015 dataset.

negative regulation of synaptic vesicle clustering Gene Set

From GO Biological Process Annotations 2015

genes participating in the negative regulation of synaptic vesicle clustering biological process from the curated GO Biological Process Annotations 2015 dataset.

abnormal synaptic vesicle clustering Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the abnormal synaptic vesicle clustering phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

regulation of AMPA glutamate receptor clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the regulation of AMPA glutamate receptor clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

gamma-aminobutyric acid receptor clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the gamma-aminobutyric acid receptor clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

regulation of skeletal muscle acetylcholine-gated channel clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the regulation of skeletal muscle acetylcholine-gated channel clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

negative regulation of skeletal muscle acetylcholine-gated channel clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the negative regulation of skeletal muscle acetylcholine-gated channel clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

receptor clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the receptor clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

clustering of voltage-gated sodium channels Gene Set

From GO Biological Process Annotations 2023

genes participating in the clustering of voltage-gated sodium channels biological process from the curated GO Biological Process Annotations 2023 dataset.

skeletal muscle acetylcholine-gated channel clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the skeletal muscle acetylcholine-gated channel clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

AMPA glutamate receptor clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the AMPA glutamate receptor clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

NMDA glutamate receptor clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the NMDA glutamate receptor clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

regulation of receptor clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the regulation of receptor clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

synaptic vesicle clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the synaptic vesicle clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

positive regulation of receptor clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the positive regulation of receptor clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

negative regulation of synaptic vesicle clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the negative regulation of synaptic vesicle clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

clustering of voltage-gated potassium channels Gene Set

From GO Biological Process Annotations 2023

genes participating in the clustering of voltage-gated potassium channels biological process from the curated GO Biological Process Annotations 2023 dataset.

signal clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the signal clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

positive regulation of skeletal muscle acetylcholine-gated channel clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the positive regulation of skeletal muscle acetylcholine-gated channel clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

regulation of synaptic vesicle clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the regulation of synaptic vesicle clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

postsynaptic density protein 95 clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the postsynaptic density protein 95 clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

gephyrin clustering involved in postsynaptic density assembly Gene Set

From GO Biological Process Annotations 2023

genes participating in the gephyrin clustering involved in postsynaptic density assembly biological process from the curated GO Biological Process Annotations 2023 dataset.

guanylate kinase-associated protein clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the guanylate kinase-associated protein clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

neuronal ion channel clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the neuronal ion channel clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

regulation of postsynaptic density protein 95 clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the regulation of postsynaptic density protein 95 clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

neuroligin clustering involved in postsynaptic membrane assembly Gene Set

From GO Biological Process Annotations 2023

genes participating in the neuroligin clustering involved in postsynaptic membrane assembly biological process from the curated GO Biological Process Annotations 2023 dataset.

positive regulation of AMPA glutamate receptor clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the positive regulation of AMPA glutamate receptor clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

glycine receptor clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the glycine receptor clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

regulation of glutamate receptor clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the regulation of glutamate receptor clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

neurotransmitter-gated ion channel clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the neurotransmitter-gated ion channel clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

negative regulation of receptor clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the negative regulation of receptor clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

glutamate receptor clustering Gene Set

From GO Biological Process Annotations 2023

genes participating in the glutamate receptor clustering biological process from the curated GO Biological Process Annotations 2023 dataset.

abnormal synaptic vesicle clustering Gene Set

From MGI Mouse Phenotype Associations 2023

gene mutations causing the abnormal synaptic vesicle clustering phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

synaptic vesicle clustering Gene Set

From SynGO Synaptic Gene Annotations

genes associated with the synaptic term synaptic vesicle clustering from the SynGO Synaptic Gene Annotations dataset.

regulation of AMPA glutamate receptor clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the regulation of AMPA glutamate receptor clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

gamma-aminobutyric acid receptor clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the gamma-aminobutyric acid receptor clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

regulation of skeletal muscle acetylcholine-gated channel clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the regulation of skeletal muscle acetylcholine-gated channel clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

negative regulation of skeletal muscle acetylcholine-gated channel clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the negative regulation of skeletal muscle acetylcholine-gated channel clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

receptor clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the receptor clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

clustering of voltage-gated sodium channels Gene Set

From GO Biological Process Annotations 2025

genes participating in the clustering of voltage-gated sodium channels biological process from the curated GO Biological Process Annotations 2025 dataset.

skeletal muscle acetylcholine-gated channel clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the skeletal muscle acetylcholine-gated channel clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

AMPA glutamate receptor clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the AMPA glutamate receptor clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

NMDA glutamate receptor clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the NMDA glutamate receptor clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

regulation of receptor clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the regulation of receptor clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

synaptic vesicle clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the synaptic vesicle clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

gephyrin clustering involved in postsynaptic density assembly Gene Set

From GO Biological Process Annotations 2025

genes participating in the gephyrin clustering involved in postsynaptic density assembly biological process from the curated GO Biological Process Annotations 2025 dataset.

guanylate kinase-associated protein clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the guanylate kinase-associated protein clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

neuroligin clustering involved in postsynaptic membrane assembly Gene Set

From GO Biological Process Annotations 2025

genes participating in the neuroligin clustering involved in postsynaptic membrane assembly biological process from the curated GO Biological Process Annotations 2025 dataset.

postsynaptic density protein 95 clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the postsynaptic density protein 95 clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

positive regulation of receptor clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the positive regulation of receptor clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

negative regulation of synaptic vesicle clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the negative regulation of synaptic vesicle clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

clustering of voltage-gated potassium channels Gene Set

From GO Biological Process Annotations 2025

genes participating in the clustering of voltage-gated potassium channels biological process from the curated GO Biological Process Annotations 2025 dataset.

signal clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the signal clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

positive regulation of skeletal muscle acetylcholine-gated channel clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the positive regulation of skeletal muscle acetylcholine-gated channel clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

meiotic telomere clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the meiotic telomere clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

regulation of synaptic vesicle clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the regulation of synaptic vesicle clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

broken chromosome clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the broken chromosome clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

neuronal ion channel clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the neuronal ion channel clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

regulation of postsynaptic density protein 95 clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the regulation of postsynaptic density protein 95 clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

positive regulation of AMPA glutamate receptor clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the positive regulation of AMPA glutamate receptor clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

glycine receptor clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the glycine receptor clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

regulation of glutamate receptor clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the regulation of glutamate receptor clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

neurotransmitter-gated ion channel clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the neurotransmitter-gated ion channel clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

negative regulation of receptor clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the negative regulation of receptor clustering biological process from the curated GO Biological Process Annotations 2025 dataset.

glutamate receptor clustering Gene Set

From GO Biological Process Annotations 2025

genes participating in the glutamate receptor clustering biological process from the curated GO Biological Process Annotations 2025 dataset.