Harmonizome 3.0

aurora kinase A

The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term aurka in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase AURKA from the curated KEA Substrates of Kinases dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for AURKA from the Pathway Commons Protein-Protein Interactions dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase AURKA from the curated PhosphoSitePlus Substrates of Kinases dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the AURKA gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the AURKA gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the RasGAP-AURKA/AURKB-survivin complex protein complex from the CORUM Protein Complexes dataset.

From GeneSigDB Published Gene Signatures

genes in signature reported in the publication with PubMedID 18662380-S3-AURKA from the GeneSigDB Published Gene Signatures dataset.

From GeneSigDB Published Gene Signatures

genes in signature reported in the publication with PubMedID 18698033-tableS1-AURKA from the GeneSigDB Published Gene Signatures dataset.

From NURSA Protein Complexes

proteins in the BL469 (AURKA) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL333 (AURKA) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Reactome Pathways 2024

proteins participating in the AURKA Activation by TPX2 pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the FBXL7 down-regulates AURKA during mitotic entry and in early mitosis pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Interaction between PHLDA1 and AURKA pathway from the Reactome Pathways 2024 dataset.